Ancient machinery embedded in the contemporary ribosome.

Ribosomal protein structures: insights into the architecture, machinery and evolution of the ribosome.

Models of the bacterial ribosome based on recent structural analyses are beginning to provide new insights into the protein synthetic machinery. Central to evolving models are the high-resolution structures of individual ribosomal proteins, which represent detailed probes of their local RNA and protein environments. Ribosomal proteins are extremely ancient molecules; the structures therefore al...

Ancient Iranian Urban Structure and its Situation in Contemporary City

The evolving ribosome: from non-coded peptide bond formation to sophisticated translation machinery.

Structural analysis supported by biochemical, mutagenesis and computational evidence, revealed that the contemporary ribosome's active site is a universal symmetrical pocket made of ribosomal RNA. This pocket seems to be the remnant of the proto-ribosome, a dimeric RNA assembly evolved by gene duplication, capable of autonomously catalyzing peptide bond formation and non-coded amino acid polyme...

Development of system decision support tools for behavioral trends monitoring of machinery maintenance in a competitive environment

The article is centred on software system development for manufacturing company that produces polyethylene bags using mostly conventional machines in a competitive world where each business enterprise desires to stand tall. This is meant to assist in gaining market shares, taking maintenance and production decisions by the dynamism and flexibilities embedded in the package as customers’ demand ...

The Lipid-RNA World

The simplest possible beginning of abiogenesis has been a riddle from the last century, which is most successfully solved by the Lipid World hypothesis. However, origin of the next stages of evolution starting form lipids is still in dark. We propose a ‘Lipid-RNA World Scenario’ based on the assumption that modern stable lipid-RNA interactions are molecular fossils of an ancient stage of evolut...